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Om Prakash Singh, PhD
Scientist
ICMR-National Institute of Malaria Research
Sector 8, Dwarka, New Delhi-110077
Welcome to My World of Science and Curiosity
Advancing Insights in Genomics and Vector Biology
Greetings!
I’m Om Prakash Singh, a retired Scientist G and former Director-in-Charge at the ICMR-National Institute of Malaria Research, New Delhi, now working as a genomics consultant. With over three decades of research, my work is centered around advancing malaria vector biology, particularly exploring the differential responses of cryptic species to insecticide resistance and vectorial competence. I specialize in developing molecular tools to identify sibling species of malaria vectors and uncovering molecular markers for insecticide resistance, including the role of gene duplication. My contributions, backed by multiple research grants and over 100 peer-reviewed publications, drive innovative, integrated strategies for effective malaria control. I’m passionate about translating molecular insights into practical solutions to combat malaria.​
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Currently, I’m exploring the genomics of malaria vectors, diving into topics like gene duplications and insecticide resistance, while also reflecting on broader questions about health and science.
RESEARCH EXPERIENCE
2024-Present
Consultant (Genomics)
ICMR-NATIONAL INSTITUTE OF MALARIA RESEARCH
New Delhi
2015-2022
Scientist G (Director Grade)
ICMR-NATIONAL INSTITUTE OF MALARIA RESEARCH
New Delhi
1995-2015
Scientist (C, D, E & F)
ICMR-NATIONAL INSTITUTE OF MALARIA RESEARCH
New Delhi
1986-1994
Scientist (B & C)
ICMR-REGIONAL MEDICAL RESEARCH CENTRE
Jablapur
RECENET PUBLICATIONS (2022-2025)
Under Review
Singh OP*, Mittal R, Dixit R. Is Aedes nr. albopictus synonymous with Aedes pseudalbopictus? Sci Rep. (Preprint bioRxiv 2025.06.28.661682; doi: 10.1101/2025.06.28.661682)
Singh OP*, Kaur T. Reporting of T1520I and F1534C knockdown resistance (kdr) mutations in Aedes albopictus from northern West Bengal (India) by Modak & Saha is a probable case of mistaken species identity of Aedes aegypti. Sci Rep. (Preprint version doi 10.31219/osf.io/cnh5p)
2025
Agrohi P, Garg S, Biswas S, Maurya P, Kumar V, Goswami B, Sil SK, Singh MP, Chand SK, Shalini S, Singh OP, Dhangadamajhi G, Ramalingam S, Mallick PK, Singh S*. Decoding the multifaceted role of erythrocyte PMCA4b in oxidative stress mediated malaria protection and artemisinin resistance. mBio. (Preprint bioRxiv 2024.12.17.628803 doi: 10.1101/2024.12.17.628803)
Singh OP*, Dixit R, Weetman D. Novel kdr mutations in human lice: artifacts or emerging resistance? Trends Parasitol. 2025; 41(7): 521-524. doi: 10.1016/j.pt.2025.05.011
Kuar T, Kushwah RBS, Pradhan S, Das MK, Weetman D, Dixit R, Singh OP*. Knockdown-resistance (kdr) mutations in Indian Aedes aegypti populations and lack of recombination among haplotypes bearing V1016G, F1534C and F1534L kdr alleles. PLoS Negl Trop Dis. 2025; 19:e0013126 10.1371/journal.pntd.0013126
De TD, Pelletier J, Gupta S, Kona MP, Singh OP, Dixit RC, Ignell R, Karmodiya K✻. Diel modulation of perireceptor activity influences olfactory sensitivity in diurnal and nocturnal mosquitoes. FEBS J. 025; 292: 2095-2118 doi: 10.1111/febs.17418
Prashar C, Devkar H, Vandana V, Kona MP, Singh OP, Das R, Vashisht K, Thakur N, Pandey KC✻. Potent targeted larvicidal activities of marine-derived Bacillus sp. bacterial extracts on mosquito vectors. Sci Rep. 2025; 15:8094 doi:. 10.1038/s41598-024-80777-5
Shalini S, Mishra N, Verma S, Kale S, Mallick PK, Prajapati SK, Kumar A, Srivastava N, Joshi H, Eapen A, Singh OP. Characterization of genes involved in hemoglobin degradation in Plasmodium vivax isolates from Chennai, India, and species of non-human primate malaria. Infect Genet Evol. 2025; 135: 105823. doi: 10.1016/j.meegid.2025.105823
2024
Kumar J, Kumar A, Gupta Y, Vashisht K, Kumar S, Sharma A, Kumar R, Sharon A, Tripathi PK, Das R, Singh OP, Singh S, Chakraborti S, Sunil S, Pandey KC✻. A Cub and Sushi domain containing protein with esterase like activity confers insecticide resistance in Indian malaria vector An. stephensi. J Biol Chem. 2024; 300(10): 107759. doi: 10.1016/j.jbc.2024.107759
Yadav K, Saurav G, Rana V, Rawat N, Kaushik A, Jamwal R, Singh OP. Rajagopal R✻. Polyubiquitin protein of Aedes aegypti as an interacting partner of dengue virus envelope protein. Med Vet Entomol. 2024 ;38(1):48-58 doi: 10.1111/mve.12696
Kale S, Uplekar SM, Bandyopadhyay N, Rao PN, Ali SZ, Sharma SK, Tandel N, Patel A, Singh R, Dank A, Ravishankaran S, Lakshmi Priya GS, Asokan A, Eapen A, Singh OP, Carlton JM✻, Mallick PK. Antimalarial drug resistance profiling of Plasmodium falciparum infections in India using next-generation sequencing. Front Malar. 2024; 2: 1363969. doi: 10.3389/fmala.2024.1363969
Rahi M, Mishra A, Chand G, Baharia RK, Hazara R, Singh S, Khan S, Sreehari U, Kamaraju D, Kumar G, Gupta SK, Sharma A, Raghavendra K, Gunasekaran K, Singh OP, Subbarao SK. Malaria vector bionomics: Countrywide surveillance study on implications for malaria elimination in India. JMIR Public Health Surveill. 2024; 10: e42050 doi: 10.2196/42050
2023
Singh OP✻, Kaur T, Sharma G, Kona MP, Mishra S, Mallick PK. Molecular tools for early detection of invasive malaria vector Anopheles stephensi mosquito. Emerg Infect Dis. 2023; 29(1): 36-44. doi: 10.3201/eid2901.220786 PMID: 36573521
Mallick PK, Sindhania A, Gupta T, Singh DP, Saini S, Singh OP✻. First report of classical knockdown resistance (kdr) mutation, L1014F, in human head louse Pediculus humanus capitis (Phthiraptera: Anoplura). Med Vet Entomol. 2023; 37(2):209-212. doi: 10.1111/mve.12596 PMID: 35822871
Yadav K, Rana VS, Kaushik A, Saurav GK, Rawat N, Kumar A, Sunil S, Singh OP, Rajagopal R✻. Mucin protein of Aedes aegypti interacts to dengue virus-2 and influences viral infection. Microbiol Spectr. 2023; 11(2):e02503-22. doi: 10.1128/spectrum.02503-22 PMID: 36847498
Sindhania A, Lohani HP, Kona MP, Kaur T, Kaushal BR, Singh OP✻. Molecular forms of the Indian Anopheles subpictus complex differ in their susceptibility to insecticides and presence of knockdown resistance (kdr) mutations in the voltage-gated sodium channel. PLoS ONE. 2023; 18(2):e0280289 doi: 10.1371/journal.pone.0280289 PMID: 36730315
Sumitha MK, Kalimuthu M, Kumar MS, Rajaiah P, Pradeep NK, Sunish IP, Balaji T, Devojit KS, Goyal D, Suman DS, Srivastava H, Bhowmik IP, Vaishnav K, Singh OP, Patil P, Tyagi S, Mohanty S, Barik TK, Sreehari U, Kumar A, Gupta B✻. Genetic differentiation among Aedes aegypti populations from different eco-geographical zones of India. PLoS Negl Trop Dis. 2023; 17(7):e0011486. doi: 10.1371/journal.pntd.0011486 PMID: 37498944
Atul, Choudhary P, Gupta S, Shoaib R, Pasupureddy R, Gotal B, Kumar B, Singh OP, Dixit R, Singh S, Akhtar, M, Kapoor N, Pande V, Chakraborti S, Vashishth K, Pandey KC✻. Artemisinin resistance in P. falciparum: Probing the interacting partners of Kelch13 protein in parasite. J Glob Antimicrob Resist. 2023; Aug 24, S2213-7165(23)00137-6. doi:10.1016/j.jgar.2023.08.012, PMID: 37633420
2022
Dykes CL, Sharma G, Behera AK, Kapoor N, Paine MJI, Donnelly MJ, Singh OP✻. Tandem duplication of a genomic region encoding glutathione S-transferase epsilon-2 and -4 genes in DDT–resistant Anopheles stephensi strain from India. Sci Rep. 2022; 12: 17872. DOI: 10.1038/s41598-022-21522-8 PMID: 36284104
Kumari V, Prasad KM, Kalia I, Sindhu G, Dixit R, Rawat DS, Singh OP, Singh AP, Pandey KC✻. Dissecting the role of Plasmodium metacaspase-2 in malaria gametogenesis and sporogony. Emerg Microbes Infect. 2022; 11(1): 938-955. DOI: 10.1080/22221751.2022.2052357 PMID: 35264080
Verma S, Chakraborti S, Singh OP, Pande V, Dixit R, Pandey AV, Pandey KC✻. Recognition of fold and function-specific sites in the ligand-binding domain of thyroid hormone receptor-like family. Front Endocrinol. 2022: 13:981090. DOI: 10.3389/fendo.2022.981090 PMID: 36246927
Singh OP✻, Mishra S, Sindhania A, Kaur T, Srihari U, Das MK, Kapoor N, Sharma G, Gupta B. Evaluation of intron-1 of odorant-binding protein-1 of Anopheles stephensi as a marker for the identification of biological forms or putative sibling species. PLoS ONE. 2022; 17 (7): e0270760. DOI: 10.1371/journal.pone.0270760 PMID: 35862377
Carlton JM✻, Eapen A, Kessler A, Anvikar AR, Hoffmann A, Singh OP, Sullivan SA, Albert S, Sahu PK, Mohanty S, Wassmer SC. Advances in basic and translational research as part of the Center for the Study of Complex Malaria in India. Am J Trop Med Hyg. 2022; 107:97–106 DOI: 10.4269/ajtmh.21-1333. PMID: 36228919
Lather M, Mallick PK, Sharma D, Kale S, Dang AS, Adak T, Singh OP✻. Population genetic structure of the malaria vector Anopheles fluviatilis species T (Diptera: Culicidae) in India. Med Vet Entomol. 2022; 36:194-202. DOI: 10.1111/mve.12566 PMID: 35182085
Surendran SN✻, Kesavan L, Jayadas TPP, Sivabalakrishnan K, Tharsan A, Liyanagedara N, Eswaramohan T, Raveendran S, Singh OP, Ramasamy R. Morphological and odorant-binding protein 1 gene intron 1 sequence variations in Anopheles stephensi from Jaffna city in northern Sri Lanka. Med Vet Entomol. 2022; 34:496-502; DOI: 10.1111/mve.12595 PMID: 35838413
Vandana V, Kona MP, Kumar J, Singh OP, Pandey KC✻. A comprehensive overview of the existing microbial symbionts in mosquito vectors: an important tool for impairing pathogen transmission. Exp Parasitol. 2022; 243:108407. DOI: 10.1016/j.exppara.2022.108407 PMID: 36349579
Baharia RK, Kaur J, Sindhania A, Sharma G, Srivastava HC, Pant CS, Rahi M, Raghavendra K, Singh OP. Bionomics of Anopheles culicifacies sensu lato in two malaria endemic districts of central Gujarat, India. J Arthropod Borne Dis. 2022; 16(2): 108–123. DOI: 10.18502/jad.v16i2.11802 PMID: 37038509
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